引用文本：杨云英, 张素娅, 毛雪娇, 等. 局部湿敷加常压氧疗法对直肠癌/肛管癌患者放射治疗所致的放射性皮炎的治疗效果：一项探索性研究[J/CD]. 消化肿瘤杂志（电子版）, 2025, 17(3):400-404.

作者：杨云英1，张素娅1，毛雪娇1，叶思欣1，高雅丽2

单位：1. 中山大学附属第一医院护理部 放射治疗科，广东 广州 510080；2. 中山大学附属第一医院皮肤科，广东 广州 510080

Authors：Yang Yunying1, Zhang Suya1, Mao Xuejiao1, Ye Sixin1, Gao Yali2

Unit：1. Department of Radiation Oncology, Department of Nursing, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong, China；2. Department of Dermatology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong, China

摘要：

目的 探讨局部湿敷加常压氧疗法对直肠癌/肛管癌放射治疗（简称放疗）所致放射性皮炎的治疗效果。方法 回顾性纳入2017年8月至2024年7月在中山大学附属第一医院接受放疗的18例直肠癌/肛管癌患者，其中10例接受根治性放疗，5例接受术前新辅助同期放化疗，3例接受术后辅助放化疗。对出现肛周皮肤放射性皮炎的患者每天进行2次局部湿敷加常压氧气治疗，直到伤口愈合。记录和评估氧疗前及氧疗后3 d、5 d、10 d患者放射性皮炎分级和数字分级评分法（numerical rating scale, NRS）评分的差异。结果 共13例患者出现3级放射性皮炎，5例患者出现2级放射性皮炎。氧疗前及氧疗后3 d、5 d、10 d放射性皮炎分级的中位数分别为3.00(2.25, 3.00)级及2.50(2.00, 3.00)级、2.00(2.00, 2.00)级、1.00(1.00, 2.00)级；NRS评分的中位数分别为6.00(4.25, 6.00)分、3.00(3.00, 3.75)分、2.00(1.25, 2.75)分、1.00(1.00, 2.00)分。不同时间点的放射性皮炎分级（X²=42.066，P<0.001）、NRS评分（X²= 50.122，P<0.001）差异有统计学意义。与氧疗前相比，氧疗后5 d及10 d的放射性皮炎分级降低（均P<0.001）；氧疗后3 d、5 d及10 d的NRS评分降低（均P<0.001）。结论 局部湿敷加常压氧疗法可有效缓解直肠癌/肛管癌放疗患者的放射性皮炎和皮肤疼痛。

关键词：直肠癌；肛管癌；放射性皮炎；局部湿敷；氧气疗法

Abstract：

Objective To investigate the therapeutic effect of localized hydropathic compresses combined with normobaric oxygen therapy on radiodermatitis due to radiotherapy for rectal/anal canal cancer. Method 18 patients with rectal/anal canal cancer receiving radiotherapy at the First Affiliated Hospital of Sun Yat-sen University from August 2017 to July 2024 were retrospectively included, of which 10 received radical radiotherapy, 5 received preoperative neoadjuvant concurrent radiochemotherapy, and 3 received postoperative adjuvant radiochemotherapy. Patients who developed radiodermatitis of the perianal skin were treated with localized hydropathic compresses combined with normobaric oxygen therapy twice daily until wound healing is achieved. Differences in radiodermatitis grades and numerical rating scale (NRS) scores were recorded and evaluated in patients before oxygen therapy and 3 d, 5 d, and 10 d after oxygen therapy. Result A total of 13 patients developed grade 3 radiodermatitis and 5 patients developed grade 2 radiodermatitis. The median radiodermatitis grades before oxygen therapy and 3 d, 5 d, and 10 d after oxygen therapy were 3.00 (2.25, 3.00), 2.50 (2.00, 3.00), 2.00 (2.00, 2.00), and 1.00 (1.00, 2.00), respectively; and the median NRS scores were 6.00 (4.25, 6.00), 3.00 (3.00, 3.75), 2.00 (1.25, 2.75), and 1.00 (1.00, 2.00), respectively. The differences in radiodermatitis grades (X²=42.066, P<0.001) and NRS scores (X²= 50.122, P<0.001) at different time points were statistically significant. Compared with the pre-oxygen therapy, the radiodermatitis grades were lower at 5 d and 10 d after oxygen therapy (both P<0.001); and the NRS scores were lower at 3 d, 5 d, and 10 d after oxygen therapy (all P<0.001). Conclusion Localized hydropathic compresses combined with normobaric oxygen therapy can effectively relieve radiodermatitis and skin pain in patients with rectal/anal canal cancer undergoing radiotherapy.

Key words：Rectal cancer; Anal canal cancer; Radiodermatitis; Localized hydropathic compresses; Oxygen therapy

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