引用文本：高敏, 乌新林. 缺氧时外泌体在消化道肿瘤血管生成中的作用与研究进展[J/CD]. 消化肿瘤杂志（电子版）, 2025, 17(3):386-391.

作者：高敏1, 乌新林2

单位：1.内蒙古医科大学第一临床学院，内蒙古　呼和浩特　010050；2.内蒙古医科大学附属医院胃肠外科，内蒙古　呼和浩特　010050

Authors：Gao Min1, Wu Xinlin2

Unit：1. Affiliated First Clinical College of Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia，China；2. Department of Gastrointestinal Surgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia，China

摘要：

缺氧是肿瘤微环境中的一个关键特征，可促进真核细胞分泌外泌体——一类具有脂质双层膜结构的细胞外囊泡。外泌体作为细胞间通信的介质，携带核酸、蛋白质等生物分子，影响肿瘤细胞的生长、迁移和血管生成。在缺氧条件下，外泌体在消化道肿瘤中扮演着重要角色，可直接作用于血管内皮细胞或通过调节肿瘤微环境中的免疫细胞和基质细胞来间接影响血管生成。本文总结了当前关于缺氧条件下外泌体在消化道肿瘤血管生成中的作用及研究进展，并探讨了其潜在的临床应用前景，旨在为开发新的治疗策略提供重要的靶点，以改善患者的预后。

关键词：缺氧；消化道肿瘤；外泌体；血管生成

Abstract：

Hypoxia is a key feature of the tumor microenvironment, which promotes the release of exosomes—extracellular vesicles with lipid bilayer membrane derived from eukaryotic cells that serve as mediators of intercellular communication. These exosomes, carrying biomolecules such as nucleic acids and proteins, further affect the growth, migration, and angiogenesis of tumor cells. Under hypoxic conditions, exosomes play important roles in digestive tract tumors. They can directly affect vascular endothelial cells, and indirectly affect angiogenesis by regulating immune cells and stromal cells in the tumor microenvironment. This article summarizes the latest understanding of the role and research advances of exosomes in the angiogenesis of digestive tract tumors under hypoxic conditions, and discusses their potential clinical applications, aiming to provide important targets for the development of new treatment strategies to improve patient prognosis.

Key words：Hypoxia; Digestive tract tumors; Exosome; Angiogenesis

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