引用文本：付广, 陈锡光, 黄秋林, 等. 基于Web of Science核心合集的结直肠黏液腺癌研究的文献计量学分析[J/CD]. 消化肿瘤杂志（电子版）, 2025, 17(2):218-226.

作者：付广，陈锡光，黄秋林，肖帅

单位：南华大学附属第一医院 胃肠外科，湖南 衡阳 421001

Authors：Fu Guang, Chen Xiguang, Huang Qiulin, Xiao Shuai

Unit：Department of Gastrointestinal Surgery, the First Affiliated Hospital of South China University，Hengyang 421001, Hunan, China

摘要：

目的 系统分析结直肠黏液腺癌研究领域的研究趋势、合作网络及热点方向，为未来研究提供参考。方法 基于Web of Science核心合集，检索2006年1月1日至2024年8月31日结直肠黏液腺癌相关文献，利用VOSviewer和CiteSpace进行国家、机构、作者、关键词及突现分析，设定最小频次阈值（国家发文量≥10篇、机构发文量≥20篇、关键词≥20次），结合聚类算法与突现强度（前10名）揭示研究动态。结果 共纳入1980篇文献（论著1804篇，综述176篇），2006年后结直肠黏液腺癌相关的文献量显著增长，2017—2023年为研究高峰期。美国（494篇）、中国（364篇）、日本（228篇）为发文量排名前3的国家。布列根和妇女医院与其他机构合作意愿最强，中山大学（44篇）则为发文量最多的中国机构。研究热点集中于生存率（416次）、微卫星不稳定性（304次）及化疗（139次）。突现分析显示，中山大学（突现强度8.87，2018—2023年）和期刊Cancers（突现强度49.57，2020—2024年）近年的影响力显著。结论　结直肠黏液腺癌发文量呈逐年递增的趋势，中国在该领域扮演越来越重要的角色，分子机制与个体化治疗为未来重点。本研究揭示了结直肠黏液腺癌的国际研究格局，为资源优化与诊治策略制定提供数据支持。

关键词：结直肠黏液腺癌；文献计量学；CiteSpace；VOSviewer

Abstract：

Objective　To systematically analyze research trends, collaboration networks, and hotspots in colorectal mucinous adenocarcinoma (CMA), aiming to provide reference for future research. Method　Based on Web of Science Core Collection, CMA-related articles published from January 1, 2006, to August 31, 2024 were retrieved. Analyses of countries, institutions, authors, keywords, and citation bursts were conducted by VOSviewer and CiteSpace. Minimum frequency thresholds were set (countries ≥10 articles, institutions ≥20 articles, keywords ≥20 occurrences), and clustering algorithms with burst detection (top 10) were applied to uncover research dynamics. Result　A total of 1980 articles (1804 original articles, 176 reviews) were included. The annual publication output on CMA-related articles increased significantly after 2006, peaking during 2017-2023. The United States of America (494 articles), China (364 articles), and Japan (228 articles) were the top three contributing countries. Brigham and Women’s Hospital exhibited the strongest collaboration propensity with other institutions, and Sun Yat-sen University (44 articles) was the leading Chinese institution with the most publications. Research hotspots focused on survival (416 occurrences), microsatellite instability (304 occurrences), and chemotherapy (139 occurrences). Burst analysis highlighted Sun Yat-sen University (burst strength 8.87, 2018-2023) and the journal Cancers (burst strength 49.57, 2020-2024) as recent influential entities. Conclusion　The annual publication output on CMA has shown an increasing trend, with China playing an increasingly pivotal role in this field. Future research priorities should focus on molecular mechanisms and personalized therapy. This study delineates the global research landscape for CMA, providing data-driven support for resource optimization and policy formulation of diagnosis and treatment.

Key words：Colorectal mucinous adenocarcinoma; Bibliometrics; CiteSpace; VOSviewer

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