作者：牛思佳，杨幼林，吴锋，马志斌，刘鸿儒，芦曦，周一楠

单位：哈尔滨医科大学附属第一医院 消化内科，黑龙 江哈尔滨 150001

Authors:  NIU Sijia, YANG Youlin, WU Feng, MA Zhingbin, LIU Hongru, LU Xi, ZHOU Yinan

Unit:  Department of Gastroenterology, the 1st Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang, China

摘要：

目的  探讨西甲硅油联合链霉蛋白酶在非麻醉胃镜检查中对疾病检出率、胃内泡沫粘液程度及胃内视野清晰程度的应用效果。方法  选择2018年8月28日至2018年9月13日到我院门诊及住院接受非麻醉胃镜检查的患者197例,随机分成研究组(99例)和对照组(98例)。研究组于胃镜检查前服用西甲硅油、链霉蛋白酶及盐酸达克罗宁胶浆;对照组在检查前只服用盐酸达克罗宁胶浆。比较两组患者的疾病检出率、胃内视野清晰程度、胃内泡沫及粘液程度。结果  研究组患者疾病检出率明显高于对照组,两组间有统计学差异(P<0.05);研究组患者胃内泡沫粘液程度及胃内视野清晰程度显著优于对照组患者,两组间有显著统计学差异(P<0.01)。结论  非麻醉胃镜检查前口服西甲硅油联合链霉蛋白酶,可有效减少胃内泡沫及粘液,提高胃内的视野清晰程度,有利于内镜医生观察胃内黏膜的病变。

关键词： 胃镜; 西甲硅油; 链霉蛋白酶; 清洁度; 疾病检出率

Abstract：

Objective  To evaluate the effect of simethicone combined with pronase on the foam and mucus in the stomach and the visional clarity of gastroscopy in unsedated gastroscopy examination. Methods  A total of 197 outpatients and inpatients who underwent unsedated gastroscopy from August 28, 2018 to September 13, 2018 were randomly divided into the study group (99 cases)and the control group (98 cases). The study group received simethicone, pronase and dacronin glue before unsedated gastroscopy, while the control group only received dacronin glue before unsedated gastroscopy. The lesion detection rate, the foam and mucus in the stomach and the visional clarity of gastroscopy were observed in the two groups. Results  The lesion detection rate in study group was significantly higher than that in control group (P＜0.05). The foam and mucus in the stomach and the visional clarity of gastroscopy in study group were significantly better than those in control group. The differences were statistically significant (P<0.001). Conclusions  Premedication with simethicone combined with pronase before unsedated gastroscopy can reduce the foam and mucus in the stomach, improve the visional clarity of gastroscopy, and be helpful to increase the lesion detection rate.

Key Words:  Gastroscopy; Simethicone; Pronase; Clear degree; Lesion dectection rate