作者：陈景耀，洪春虹，王小群

单位：中山大学附属第七医院 消化医学中心，广东 深圳 518107

Authors: Chen Jingyao, Hong Chunhong, Wang Xiaoqun

Unit:  Center of Digestive Disease, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, Guangdong

摘要：

癌症是全球健康问题,是患者死亡的主要原因。恶性肿瘤的早期诊断、早期治疗的策略已经大大改善了患者的总生存率,同时个性化的靶向药物为晚期肿瘤患治疗提供了新的机会。然而随着化疗、免疫治疗、靶向治疗日新月异的发展,晚期肿瘤患者治疗后出现药物耐药的情况层出不穷,这极大地限制了治疗效果。近年来类器官的发展为这类患者带来了治疗的福音。类器官能在体外高效培养肿瘤组织细胞,同时保留原代肿瘤细胞的生物特点。在肿瘤的测序分析、药物筛选、个性化治疗等领域发挥重要作用。本文就类器官在胃肠肿瘤临床治疗的不同应用进行综述,为晚期恶性肿瘤治疗提供新的治疗思路。

关键词：胃肠肿瘤; 类器官; 精准医疗

Abstract：

Cancer is a global health problem and the main cause of death in the world. The strategies of early diagnosis and early treatment have greatly improved the overall patient’s survival, meanwhile personalized targeted drugs provide new opportunities for patients with advanced tumors. However, after receiving treatment of chemotherapy, immunotherapy, and targeted therapy, many patients have developed drug resistance, which greatly limits the therapeutic effect. The development of organoids in recent years has brought the lights for such patients. The organoid efficiently cultivates tumor tissue cells in vitro, while retaining the biological characteristics of primary tumor cells. It plays an important role in tumor sequencing analysis, drug screening, personalized treatment and other fields. This article reviews the research progress and challenges in the application of gastrointestinal cancer organoids, and provides new treatment ideas for advanced malignant tumors.

Key Words:  Gastrointestinal cancer; Organoids; Personalized treatment