引用文本：中国早发性结直肠癌诊疗与全程管理专家共识工作组，中国抗癌协会遗传性肿瘤专业委员会. 中国早发性结直肠癌诊疗与全程管理专家共识（2026版）[J/CD]. 消化肿瘤杂志（电子版）, 2026, 18(3): 317-328.

单位：中国早发性结直肠癌诊疗与全程管理专家共识工作组，中国抗癌协会遗传性肿瘤专业委员会

Unit：Expert Consensus Working Group on Diagnosis, Treatment and Whole-Course Management of Early-Onset Colorectal Cancer in China, Hereditary Cancer Committee of China-Anti Cancer Association

摘要：

近年来，早发性结直肠癌（early-onset colorectal cancer, EOCRC）发病率在全球范围内持续上升，中国疾病负担增长尤为迅猛。与晚发性结直肠癌相比，EOCRC患者常在症状驱动下确诊，诊断延迟更为常见，肿瘤生物学行为更具侵袭性；且患者多处于职业发展和家庭组建的关键阶段，对生育力保全、性功能保护及长期生活质量均具有迫切需求。然而，目前国内外相关指南多以总体结直肠癌人群为对象，尚缺乏针对EOCRC患者特征的系统化管理框架。鉴于此，中国抗癌协会遗传性肿瘤专业委员会组织涵盖结直肠外科、肿瘤内科、放射治疗科、病理科、遗传医学、生殖医学、心理医学及专科护理等多学科专家，基于循证医学证据并结合我国临床实践，制订了《中国早发性结直肠癌诊疗与全程管理专家共识（2026版）》。本共识涉及EOCRC的定义、流行病学特征、筛查与诊断、综合治疗策略、生育力保全与性功能保护、心理社会支持及长期随访等临床问题，共整理出18条相关推荐意见，旨在构建以多学科团队为基础的全程管理模式，实现肿瘤控制与长期生活质量并重，为EOCRC的规范化诊疗提供参考。

关键词：结直肠肿瘤，早发性；遗传筛查；全程管理；生育力保护；专家共识

Abstract：

The incidence of early-onset colorectal cancer (EOCRC) has been rising globally in recent years, with an especially rapid increase in disease burden in China. Compared with late-onset colorectal cancer, EOCRC is more often diagnosed following symptomatic presentation, with greater diagnostic delay and more aggressive biological behavior. Patients are typically at critical life stages regarding career development and family building, and have urgent needs for fertility and sexual function preservation, and long-term quality of life. However, current domestic and international guidelines mostly target the general colorectal cancer population, and a systematic management framework tailored to the specific characteristics of early-onset patients is lacking. Therefore, the Hereditary Cancer Committee of the China Anti-Cancer Association organized a multidisciplinary expert panel—including specialists in colorectal surgery, medical oncology, radiation oncology, pathology, genetic medicine, reproductive medicine, psycho-oncology, and specialized nursing—to develop the Chinese expert consensus on the diagnosis and whole-course management of early-onset colorectal cancer (2026 version), based on evidence-based medicine and Chinese clinical practice. This consensus covers clinical issues such as the definition, epidemiological characteristics, screening and diagnosis, comprehensive treatment strategies, fertility and sexual function preservation, psychosocial support, and long-term follow-up of EOCRC, and presents 18 relevant recommendations. It aims to establish a multidisciplinary team-based whole-course management model that emphasizes both tumor control and long-term quality of life, providing a reference for the standardized diagnosis and treatment of EOCRC.

Key words：Colorectal neoplasms, early-onset; Hereditary screening; Whole-course management; Fertility preservation; Expert consensus

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