引用文本：施令霞, 徐胜. 胃与结直肠多原发癌诊治研究进展[J/CD]. 消化肿瘤杂志（电子版）, 2025, 17(3):378-385.

作者：施令霞1,2，徐胜2

单位：1. 右江民族医学院，广西 百色 533000；2. 广西壮族自治区人民医院（广西医学科学院）胃肠·疝·肠瘘外科，广西　南宁　530021

Authors：Shi Lingxia1,2，Xu Sheng2

Unit：1.Youjiang Medical University for Nationalities, Baise 533000, Guangxi, China；2.Department of Gastrointestinal, Hernia, and Fistula Surgery, Guangxi Academy of Medical Sciences / People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, Guangxi, China

摘要：

胃与结直肠多原发癌是消化道相关性多原发恶性肿瘤的常见类型，具有肿瘤异质性高、治疗决策复杂等特点。随着医疗技术的进步，长期生存的胃肠原发癌患者明显增多，而胃与结直肠多原发癌的发病率及检出率亦呈升高趋势，其5年生存率显著低于单原发癌。近年来，胃与结直肠多原发癌的研究领域在流行病学特征、发病机制、新辅助治疗和转化治疗、手术治疗策略、手术方式选择、保功能手术、预后影响因素及辅助治疗与多学科协作等方面取得了一定进展，本文旨在总结其相关研究成果，为临床实践提供参考依据。

关键词：胃与结直肠多原发癌；多原发恶性肿瘤；肿瘤异质性；治疗决策；预后

Abstract：

Gastric and colorectal multiple primary cancers (GCRMPC) represent a common type of digestive tract-associated multiple primary malignancies, characterized by high tumor heterogeneity and complex therapeutic decision-making. With advancements in medical technology, the number of long-term survivors from primary gastrointestinal cancers has significantly increased, leading to a rising incidence and detection rate of GCRMPC. Notably, the 5-year survival rate of GCRMPC is significantly lower than that of single primary cancers. In recent years, research on GCRMPC has made progress in multiple areas, including epidemiological characteristics, pathogenesis, neoadjuvant and conversion therapies, surgical strategies and approaches, function-preserving surgery, prognostic factors, adjuvant therapy, and multidisciplinary collaboration. This article aims to summarize these research advancements to provide evidence-based references for clinical practice.

Key words：Gastric and colorectal multiple primary cancers; Multiple primary malignancies; Tumor heterogeneity; Therapeutic decision-making; Prognosis

注：网络优先发布