作者：赵娜，汪国建，龙爽，粟永萍，王涛

单位：陆军军医大学(第三军医大学) 军事预防医学系防原医学教研室，全军复合伤研究所，创伤、烧伤与复合伤国家重点实验室，重庆市纳米医学工程研究中心，重庆 400038

Authors:  ZHAO Na, WANG Guojian, LONG Shuang, SU Yongping, WANG Tao

Unit:  Institute of Combined Injury, State Key Laboratory of Trauma, Burn and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Army Medical University (Third Military Medical University), Chongqing 400038, China

摘要：

Kazal型丝氨酸蛋白酶抑制因子7(SPINK7),又名食管癌相关基因2 (ECRG2),是与食管癌发生发展密切相关的抑癌基因。研究显示其在食管癌组织存在表达失调,同时其短串联重复序列多态性与食管癌的易感性关系密切。机制分析表明SPINK7可通过分泌至胞外和留在细胞内两种不同的机制发挥抑癌作用。新近研究表明其表达失调与嗜酸性食管炎的发生有关。本文就SPINK7在食管癌、嗜酸性食管炎等食管相关疾病中的研究进展做一综述,并探讨该分子后续值得研究的问题。

关键词：  SPINK7; ECRG2; 抑癌基因; 食管癌; 嗜酸性食管炎

Abstract：

Serine Protease Inhibitor kazal type 7 (SPINK7), also named ECRG2 (esophageal cancer-related gene 2), is one tumor suppressor gene closely related to tumorigenesis and progression of esophageal carcinoma. Studies revealed that there were correlations between STR polymorphisms of SPINK7 and risks of esophageal squamous cell cancer. SPINK7 serve as tumor suppressor depending on both extracellular and intracellular mechanisms. Lately, SPINK7 is reported as one important inflammation regulator during eosinophilic esophagitis development. The aim of present review is to discuss the significant role of SPINK7 in esophageal diseases such as esophageal cancer and eosinophilic esophagitis, then explore the follow-up questions of SPINK7 for further investigation.

Key Words:  SPINK7; ECRG2; Tumor suppressor gene; Esophageal carcinoma; Eosinophilic esophagitis