引用文本：吴璇, 李袁飞, 陈路锋, 等. 肿瘤微环境在食管癌放疗抵抗中作用的研究进展[J/CD]. 消化肿瘤杂志（电子版）, 2025, 17(1):85-90.

作者：吴璇1，李袁飞2，陈路锋1，赵乐然1，张革红3

单位：1.山西医科大学第一临床医学院 放疗科，山西 太原 030000；2.山西医科大学第一临床医学院 肿瘤消化科，山西 太原 030000；3.山西医科大学第一临床医学院 肿瘤综合科，山西 太原 030000

Authors：Wu Xuan1, Li Yuanfei2, Chen Lufeng1, Zhao Leran1, Zhang Gehong3

Unit：1.Department of Radiation Oncology, the First Hospital of Shanxi Medical University, Taiyuan 030000, Shanxi, China；2.Department of Gastrointestinal Oncology, the First Hospital of Shanxi Medical University, Taiyuan 030000, Shanxi, China；3.Department of Comprehensive Oncology, the First Hospital of Shanxi Medical University, Taiyuan 030000, Shanxi, China

摘要：

食管癌是一种常见的消化道恶性肿瘤，放疗是其主要治疗手段之一。然而，放疗抵抗显著影响了治疗效果和患者生存率。放疗抵抗涉及肿瘤微环境、非编码RNA、细胞周期检查点调节、肿瘤干细胞等多种因素和复杂的调控机制。近年来，关于肿瘤微环境在肿瘤放疗抵抗中作用的研究越来越多。本文系统综述了肿瘤微环境参与食管癌放疗抵抗的可能机制，重点探讨了血管系统、基质成分以及免疫系统在食管癌放疗抵抗中的作用，以期为提高放疗效果和开发新的治疗策略提供理论依据。

关键词：食管癌；放疗；肿瘤微环境；免疫；缺氧

Abstract：

Esophageal cancer is a common malignant tumor of digestive tract, with radiotherapy being one of the primary treatment modalities. However, radiotherapy resistance significantly affects treatment outcomes and patient survival rates. Radiotherapy resistance involves various factors and complex mechanisms, including tumor microenvironment, non-coding RNAs, cell cycle checkpoint regulation, and cancer stem cells. In recent years, more and more studies have been conducted on the role of tumor microenvironment in tumor radiotherapy resistance. In this paper, we systematically reviewed the potential mechanisms of radiotherapy resistance in esophageal cancer involved in the tumor microenvironment, focusing on the roles of the vascular system, stromal components, and the immune system in the resistance to radiotherapy in esophageal cancer, and expected to provide a theoretical basis for improving the efficacy of radiotherapy and developing new therapeutic strategies.

Key words：Esophageal cancer; Radiotherapy; Tumor microenvironment; Immunity; Hypoxia

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